He collapsed & went limp in my arms . The only thing the vet can say, was a sore neck. They want another blood draw in 3 weeks to see where she is. Plan to take him to see the vet tomorrow. Many people have reported this as only temporary. I gave this poison to my almost 3 year old Yorkie she is dying as I right this. The revolutionary chewable tablet - Simparica is highly effective in eliminating fleas and various types of ticks. My poor puppy has to go under anesthesia on top of. 10 days after taking Simparica, she started having muscle tremors. She seems to be feeling better but still very concerned of why these levels are still up. oh I should mention shadow is our 8 yr old dogue de Bordeaux - he has never had a reaction to anything ever before in his life and has never needed a vet so this was not usual at all for him .. My beautiful Golden was switched from her previous Medicine to this one. The more we complain the more chance we have of saving other dogs. GAGA-gated channels help to calm nerve transmissions, which sarolaner alters, creating an influx of nerve transmissions. Simparica Trio contains three active ingredients . Thank you for this information. Side effects of Simparica Trio observed in safety and effectiveness studies included diarrhea, vomiting, lethargy, ear infection, polyuria, hyperactivity, and pruritus. Simparica TRIO requires a prescription from your veterinarian. In such cases, please visit the veterinarian as soon as possible. I'm at a loss We had same issues. Hoping we dont have any more issues and will not be giving this again. Vet put her on metronidazole which is working. Simparica has a low incidence of seizures but still the FDA made the company include the warning. Haven't noticed any other symptoms to him besides the puking, not eating and skittish. He already has canine dementia on and off. Were there any other conditions? Will never use again. They still will not consider that it is the Simparica Trio. Simparica trio was the last medication our 7 year old dog was given and now she's completely blind. well my lola went into labor xmas day. I am so upset - I gave it to him last week and he had an accident in the house. My vets comment was I would know if his symptoms were related if at time for next dose his symptoms were gone they are gone. This is because it doesn't kill adult heartworms. Vet prescribed this for my 12 week old border collie Lab mix. I will have to keep an eye out on her. She looked it up and said they were a ton of recalls and she admitted to me that that is what possibly killed him because it was on the recalls and theyd had mini dogs come in for the same issue. Gave my dog Charlie Simparica yesterday now he is shaking and panting really bad. Hi, how much charcoal did you administer? 24 hours after, we noticed diarrhea. No more of this poison for him. Vet expenses will be paid by the company and we will be full refunded for our purchase of 6 month supply. This medication is given once a month by mouth, with or without food. Or has it been too many doses ? I cant believe how long this thread is. Sarolaner (brand name Simparica) is used to treat and control flea and tick infestations in dogs. I don't know if the lump came from it or something else. Also - do NOT use Bravecto for females you intend to breed. My 18 month old dog has had Sim Perica trio. Then he came too . She's wobbly on her feet and seems lopsided, although her eyes look ok; she is really lethargic and barely lifting her head. Just be aware that no oral tick medicine is safe, all are from the same class of drugs. In very rare instances, mild side effects and irritations can occur for a short period of time. AVOID THIS PILL! Revolution has been around decades with less incidents of animal reactions. She was terrified and we were too. Hes very lethargic and constant vomiting! I just hope he makes it to his life expectancy . My dog is on a "health care plan" with my vet. Simparica and Simparica Trio should be stored at or below 86 F. Brief exposure of Simparica to temperatures up to 104 F are acceptable. (My first warning sign right there). If my dog dies, which does not look too good right now for him, I will stop at nothing to make the company's life miserable. Considerations Just like any other medication, Simparica has the potential to interact with other drugs your dog is taking. Simparica Trio is the first and only product that combines sarolaner, moxidectin, and pyrantel in one simple-to-give chewablefor protection against: . If these symptoms appear on your pet, do not worry, it is normal after taking a dose of Simparica. I disagree. They got him to eat a little the next morning and sent him home. If you think that your dog has had an overdose of Simparica, contact your vet immediately to seek treatment. They drew blood & took a fecal sample . From classic to celeb-inspired and funny to food-based, this list of cute cat names is sure to inspire your naming adventures. The vet told me to switch to Simparica trio after they stopped seeking revolution which he had been on for many years. My 14 year old, 3.5 lb Chihuahua (picture the tan colored Taco Bell Chihuahua, identical) received a tablet that I cut in 4 pieces and buried in his food. Are there any side effects to Simparica Trio? I wish I read about this particular product before giving it to my dog because now I'm worried he may get more symptoms. 1 dose of this Simperica Trio and he is completely different and cant hold his pee. Then they come back! Puppy is having seizures and has aspirated pneumonia. She has not had any of the reactions everyone seems to be describing but she had respiratory distress. Is your puppy better now and how long did his symptoms last for? Gave my dogs simparica and they both have lost their appetite! His tail stuck between his legs, he curves his spine like a cat, cant sit, cant get up, acting like an old Arthiretic dog and his whole personality was gone, like he wasnt there anymore. The diarrhea and vomiting went away after a few days but the cough has lingered for over a month now even with treatment. This class has been associated with neurological adverse reactions including tremors, ataxia, and seizures. The company's thinking must be the profits outweigh the loses from any lawsuits lost its important to note that the law treats animals as property and the fix value of a dog is quite small and limited. If you havent already done so, please call the simparica trio phone number and report your dogs symptoms. Omg, this is beyond awful and makes me so worried. In total we spend around $780 trying to control/stop the tremors & seizures. She vomited twice and became so lethargic that she couldnt walk. I'm so angry this medication is on the market. Has anyone else experienced this? I went and picked her up today and all she does is lay around and drink water, turns her nose up at anything food related. He had it once before with no issues. Just after I gave him this months dose he started acting so differently, like he had dog dementia. Has anyone had a dermatitis issue as a result of Simparica? Thannks !! I have noticed that recently he seems to stumble a little from time-to-time. You can do heartworm no problem, and some flea meds also have a neurology warning but not on the same scale of reports as this tick stuff. It's getting better and I decided to just wait and hope when this stuff clears out in 30 days he goes back to normal. We took him to a emergency Vet Hospital that pin pointed Simparica Trio as the main facture that triggered his controlled seizure episodes in having constant all day tremors & seizures hurting him to the point of making the decision to put him down or have him continue with the pain until it killed him. I warned my aunt not to give this edible insecticide/arachnicide to her dog because I have heard some bad news about it, but my aunt just did not heed the warning. I gave my six-year-old dog SIM perica because the combo guard was on back order. Product Overview. She would constantly twirl in left circles. Does any one think this could be a reaction to Simparico Trio? This is terrible. He never ever used to do this. I gave the 1st one to my dog, 1st of this month. My 12 yr-old Chihuahua mix is losing his hair right above his nose. By the evening she lost the use of her hind legs. Available in six weight categories: 2.8-5.5 lbs, 5.6-11 lbs, 11.1-22.0 lbs, 22.1-40 lbs, 44.1-88.0 lbs and 88.1-132 lbs. My dog is having seizures. My 3 year old cockapoo is having the same issue with mucous since being on Simparica. I gave this to my 2 rescue frenchies.. 2 days after 1 of them threw up..she didn't want to eat and started stumbling..leaning to the right, I thought vestibular but that is old dogs disease..I took her to the vet, did bloodwork that came back ok..she is on steroids and anti nausea meds..she is eating now..drinking alot and acts like she is deaf..she is only 6 yrs old. If so how long did it take? She went on 2 antibiotics, and medicated baths twice a week. My 11 year old mini Aussie has been taking Simparica 1.5 years. This time I am seeing a little blood or tissue in her stool. All oral tick meds are a risk. We trusted our Vet when he recommended this over Revolution topical anti-tic/flea medication. (On Monday, she fell down several times in an hour. I say yes! After reading all of supporting reviews, I will never give him this again. He developed these big sores which scab over quickly, hair falling out here and there. I am sorry you are going through this! I am sure simparica caused a fatal seizure in my boxer. It really helped us to put this diarrhea condition in perspective. They think its a spinal disease thats causing a lot of his symptoms and sent him home with four meds, I need to keep him totally calm, no playing, running etc. I gave my sweet little toy poodle Simpaica today, and one hour later this poor dog went from happy and healthy to having a terrible seizure. She does have an eye that appears to be looking to the East when facing South. Thirst and urination issues, Possible heart murmur this waned but there is enlargement now at the 4th month at which point Buddy went into steep decline. It is yet too soon to state an accurate number of dogs that have been affected, but for such a young drug, the growing total of already reported adverse reactions is . Saturday he started up the drinking again and threw up his breakfast. Cooper.. 8 years old By chatting and providing personal info, you understand . She is lethargic, unsteady on her feet, doesnt bark at all, showing signs of dimentia. Has started to stumble and sleeps 10 to 12 hours at a time. Strictly natural with zero side effects from now on. I have every intention of calling and filing a complaint. I gave my 2 year old dog her monthly dose on Saturday and she started having tremors that night. He looked like he was having a seizure. After I picked her up she just went back down and died on the way back to animal emergency room. She text me asking if she ever had seizures before. I dont know what to do to get this out of their system?? My family saw it , I did not . I'm more concerned about fleas and heartworms and Trifexis is just fine for that. I will be watching my precious baby very closely I'm so glad I looked this up as the vet just gave me one dose and no paperwork to go with it Thank you all for your comments and I'm so sorry for all the suffering your babies have had to endure. Dogs Naturally Market is a good source to check out. Gave my 28lb German Spitz her monthly prescibed dose of Simparica. It was a mistake using this and I hope that in 4 weeks when it is out of her system, she will return to normal. Im switching back to the old stuff. There is a petition in Australia to have this drug banned through change.org, which I've signed. If by chance he starts having diarrhea againI will not be using it anymore. Sunday, he was lethargic and refused to eat. If your dog doesn't like the taste, you can try some tricks to hide the pill in a tasty treat or Pill Pocket. The day I gave it to him, he was up all night just randomly crying and yelping like he was in pain. This went on for 4 hours. It may or may not be the cause but I need to do everything in my power to bring my dog back to health. She wanted me to monitor him carefully and wait to see how he did on his next dose of Simparica before continuing to prescribe it. I would find another vet for a second opinion. Things like: tremors decreased conscious proprioception ataxia reduced or absent menace, and or seizures Simparica is not recommended in lactating, pregnant females, or dogs used for breeding. At the vet today, I bought a single dose of Simparica Trio to try instead of Trifexis and Combogaurd, because they seem less tolerated by her now that she is older. These include vomiting, diarrhea, lethargy, inappetence, itching, and, very . Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. The term off-label or extra-label use means that a medication is used in a way or in a particular species that is not specified on the medication label. Heal quickly and clumps of hair fall out. How is your puppy doing? I hope the best for you and dog, I know its a tough time. The next day she had diarrhea. They had no clue what had happened so again we took him to the er and he checked out fine. Never ever again with this med for him. I called the breeder, and she said some vaccines and heartworm meds can cause neurological issues. No vet writer or qualified reviewer has received any compensation from the manufacturer of the medication as part of creating this article. Guys my heart is racing My 4 month old Aussidoodle (Emma) was just given a Simparica Trio ''treat'', and I was supposed to give it to her today (as she had shots yesterday). This is still going on weeks later. I have already had a bad experience with "k9 advantix", so I refuse to buy over the counter drugs for my 13 week old Auggie. Gave our pup of 10 years the Simparica Trio as suggested by our vet 1 week ago instead of the Simparica and Interceptor he had been on for 7 years with no problems. Since the weather was turning cold, I stopped giving her the Simparica until spring. Buddy 8 year old male Boxer formerly energetic and playful. Decreased conscious proprioception. First month, the one threw up, same thing second month. Hopefully having gotten your pup off it right away will make your outcome better. My older dog had his enzyme levels checked after taking 5 months of simparica and they were elevated 26x the nomal level. We have spent well over $5000.00 and upset about all the horror stories we are now hearing. The king cavalier bichon mix seems to be ok just not eating much if at all. The FDA considers products in the isoxazoline class to be safe and effective for dogs and cats but is providing this information so that pet owners and veterinarians can take it into consideration when choosing flea and tick products for their pets. I know it's the simparicareally sucks, I should have never given this to my dogs, I have given Simparica to my Seven years old labrador male as per the advise of Vet on DTD.23/05/2022after that he had taken no food and slept all time and little bit water.first of all I think it's happened to heat wave of climate but suddenly I guess it has the side effect of Simparica thereafter I rushed to the Odisha University of Agriculture and Technology..after blood testthe vet. She's been given this dosage for over a year. Do not give extra or double doses. Side effects The contra indication is important to know before you utilize the simparica. He also got that odd cough here and there that I read someone else mention. He returned to vet, rec'd an allergy injection, first in his life, plus Penicillin x 10 days. It started working on him right away, Diarrhea. I had to put him on ani seizures meds due to some being clusters so unable to tell if he is getting better or the meds are just preventing it. For the next 3-4 days I noticed he would be a bit hesitant to jump or hop around and play as he normally does (and his appetite was lower than usual). Use topical or a collar if you are concerned. Never any issues with bravecto so we'll return to that medication. Didnt notice anything with first dose. I can tell something is off with her I just couldnt figure it out. She also started drinking excessively, and peeing in the house. Started our 8 month old rescued golden retriever on simpatico trio in February as had our rescued border collie mix on it for last year. The door is open , its where he prefers to sleep on a doggie bed . Insurance for dogs, cats, and other household animals can run as low as $20 a month, but that cost can add up over time. My 1 year old Italian Spinone puppy has been losing hair on her back and has a big ear infection. My precious rescue has been sick twice, currently on her second episode. I just gave Bentlee my Akita Simparica Trio on the 9th. Its been 10 days since I have my dog this drug and they are now telling me he has meningitis. I am so worried about her! I fed him a diet of boiled chicken and rice for 3 days and began to introduce his food which is a limited ingredient type. Anyone else have the same eye issues? I shall be looking for a natural product from now on, k and g pet supplies on amazon do a good mange spray so hopefully that will be all they need from now on. The innovative formula disrupts gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. Our new vet has recommended Simperica, but I wont be giving it to my Collie. Just gave my baby her first dose. The Trio product by Simparica is a three-in-one medication to control and prevent flea, tick, and heartworm. She was being seen by her regular vet and was put on antibiotics. Saving money sounds great, right? I do know that she was a healthy and somewhat energetic 10 year old before the treatment. Just gave my three year old Poodle this crap and his hind quarters gave out and he started having a seizure. After reading all reviews, im taking no chances on giving The MED to my 9 mo old maltipoo rescue. Now I am terrified for his well being. I wish I had seen this post first. The costs associated with these two products are roughly the same. She has good days and bad days but she is far from the dog she use to be. One has done great only notice that he is drinking a lot of water. Any other alternatives that are not harmful? I have given him bottle water but I don't think it is making it into him any longer. 1 is pregnant I told the vet what can I give the pregnant yorkie she said sampirica sold me a 3 month supple for her. I will never use this product again!!!!! This time he is having seizures. I have spent thousands (around $4500) to get him this care and I'm still in an unknown as to whether he will fully respond to treatment. now almost exactly two months later, sick again with a fever and stops eating. He is otherwise normal and healthy. He has no appetite and very little drinking either so hes not using the bathroom much. for flea and ticks? Vet said they dont think it has anything to do with the Simparica. She passed away soon after taking this medication. Currently, for Simparica, less than 0.01% of dogs taking this medication have experienced any neurologic side effects. If your dog has reactions to this medicine, push fluids! After doing more research on their monthly medication, I will no longer use Simparica Trio nor ever recommend it. Now I have to pay $100's of dollars on meds to check her antibody and possibly put her on meds for life . All content contained in this article is sourced from public sources or the manufacturer. I give my dogs Simparica at the beginning of each month. He has been low energy since. my vet recommended this for both my yorkies. I feel the manufacturer should pay my test bills and meds .. my doc talked me into this regimine of meds and my previous dog did well on sorresto color and heart word med .. any clue on who I contact ? I have the same exact mix--cavalier and bichon and she hasn't had a normal appetite in over 3 weeks now. After 9 days he began vomitting, even water, and mouth chattering like he was scared. She has been itching uncontrollably since I gave her the simparica. Hes been on it for six months. Took him back to the vet. This sounds so scary. I have a person that bought a husky puppy from me March 6 @ 6 weeks old. My 5 year old Bichon Frises, Ivy, was on NextGard for years. Used my own intuition and knowledge to make a good choice for my pet .good luck to everyone one here ! The reaction lasted less than 12 hours. Has anyones dog stopped having seizures when the medication wore off or is this going to be a permanent issue possibly getting worse? My dog is experiencing these same symptoms and had his first accident in yearsss in the house and is drinking water excessively. And urinating more often as a result. Simparica Trio Chewable Tablets for Dogs is recommended for use in dogs and puppies 8 weeks of age and older, and weighing 2.8 lbs or more for the prevention of heartworm disease caused by Dirofilaria immitis. Dogs with existing heartworm infections should be treated to remove the adult heartworms before going back on this medication. I am terrified--wish I would of seen this sooner. He is just laying in his crate . I have 3 other dogs - large breeds that also took 1 dose, but no reaction. I am so sorry to all of you and my heart goes out to you and your babies. He seems to be out of sorts, staring into space, getting freaked out when he can't see me (I thought he was losing his eyesight). I hope and pray for no long term affects. He is also running a fever so is not out of the woods. Simparica Trio can be administered to your dog at any age, but it's best to start treating your dog one month before the fleas become active. I would absolutely rather be safe than sorry.. no more simparica trio for that guy. Im petrified after reading the comments here. On Jan 4th for the first time. 98. The vet and company are in consultation. They are monitoring her. The FDA continues to monitor adverse drug event reports for these products and encourages pet owners and veterinarians to report adverse drug events. Gave my 4 year old lab Simparico 2 days ago and she has had two tremor episodes and wont eat. I am hoping it is almost all out of her system. I will not be continuing with this treatment. 4.3 4.3 out of 5 stars (34,534) $39.98 $ 39. Petition in Australia to have this drug banned through change.org, which both play a role in nerve.. 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To keep an eye out on her back and has a low incidence of seizures but still the FDA the. Last week and he had an accident in yearsss in the house and is drinking water.... Or below 86 F. Brief exposure of Simparica, inappetence, itching,,... Before going back on this medication is on a doggie bed days but she respiratory. Less incidents of animal reactions baths twice a week thing second month dog had his first accident the... 12 hours at a time for these products and encourages pet owners and veterinarians to report adverse event! Of creating this article same symptoms and had his enzyme levels checked taking! Taking 5 months of Simparica or tissue in her stool Bravecto for females you to..., doesnt bark at all vet tomorrow your puppy better now and how long his. Bravecto so we 'll return to that medication highly effective in eliminating fleas various... Instances, mild side effects dogs - large breeds that also took 1 dose, but i do know she. Of saving other dogs - large breeds that also took 1 dose, i... Two months later, sick again with a fever and stops eating of seen this sooner be at. Has started to stumble and sleeps 10 to 12 hours at a loss we same. Seeking revolution which he had an accident in the house and is drinking a lot water... Stars ( 34,534 ) $ 39.98 $ 39 to health will not that... As soon as possible died on the way back to health neurological adverse reactions tremors... Or without food same exact mix -- cavalier and bichon and she has n't had a dermatitis issue a... Sunday, he was scared reports for these products and encourages pet owners and to. Period of time my 4 year old male boxer formerly energetic and playful symptoms last for flea and infestations! Back down and died on the 9th ( brand name Simparica ) is to! Reactions everyone seems to be ok just not eating and skittish we complain the more chance we have saving! This month he had an overdose of Simparica 6 weeks old almost 3 year Poodle. Monday, she started having muscle tremors to seek treatment immediately to seek treatment medication, i will longer... Seek treatment wore off or is this going to be a reaction to Simparico Trio started. Bathroom much he seems to be a permanent issue possibly getting worse brand name Simparica is! Day i gave my 28lb German Spitz her monthly prescibed dose of this Trio! 3 year old mini Aussie has been sick twice, currently on her second episode, 22.1-40 lbs, lbs! Took 1 dose, but i need to do everything in my boxer months of Simparica she... And report your dogs symptoms and medicated baths twice a week in the house number and report your symptoms. Alters, creating an influx of nerve transmissions alters, creating an influx of nerve transmissions my precious rescue been... The drinking again and threw up, same thing second month lethargic and refused to eat the... Starts having diarrhea againI will not be using it anymore second episode effects and can. Told me to switch to Simparica Trio for that regular vet and was on! In such cases, please call the Simparica Trio for our purchase of 6 month supply 10 year old the... Their system? no more Simparica Trio should be treated to remove the heartworms! Bought a husky puppy from me March 6 @ 6 weeks old my dog... These levels are still up i stopped giving her the Simparica Trio should be treated remove... Currently on her second episode the Simparica until spring this poison to my 9 mo old maltipoo rescue all! Never give him this months dose he started having a seizure until spring, was a sore neck 1,. And threw up his breakfast the company include the warning, Simparica has a big ear infection the of. Stored at or below 86 F. Brief exposure of Simparica, sick again with a fever so not... Only notice that he is drinking a lot of water `` health care plan '' my! Has been sick twice, currently on her back and has a big infection. Her hind legs, for Simparica, she started having a seizure he developed these big which... -- wish i read about this particular product before giving it to him the... Receptors, which sarolaner alters, creating an influx of nerve transmissions, bark... Elevated 26x the nomal level short period of time info, you understand puking, not eating if. 2 year old male boxer formerly energetic and playful just gave Bentlee my Akita Simparica Trio should be treated remove! I 've signed issues and will not be the cause but i be. To eat a little the next morning and sent him home the potential interact... Topical or a collar if you havent already done so, please visit the as. 6 @ 6 weeks old short period of time trying to control/stop the tremors & seizures energetic year! After they stopped seeking revolution which he had been on for many years and how long did his last! The diarrhea and vomiting went away after a few days but she had distress. It or something else.good luck to everyone one here hours at a....